反应详情

To a solution of 300 mg 1H-Benzoimidazole-2-carboxylic acid in 3 mL DMF and 1 mL NEt3, 398 mg 1-Isopropyl-piperidin-4-ylamine hydrochloride and 470 mg BOP-Cl were added and the mixture was stirred for 3 h. Finally, 3 mL saturated NaHCO3 solution were added and the mixture was filtered through a chem elut® cartridge by elution with ethyl acetate. After removal of the solvent under reduced pressure the crude product was subjected to the next reaction step without further purification.

1. filtrationthe mixture was filtered through a chem elut® cartridge by elution with ethyl acetate
2. customAfter removal of the solvent under reduced pressure the crude product
3. customwas subjected to the next reaction step without further purification