Triethylamine → HCID 58956316, compound

HRID 1853439Notes

Reaction equation

HRID 1853439 reaction equation
Cl.[N+:2]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH2:9])([O-:4])=[O:3].[CH:13]1([S:16](Cl)(=[O:18])=[O:17])[CH2:15][CH2:14]1.C(N(CC)CC)C>ClCCl.Cl.O>[CH:13]1([S:16]([NH:9][CH2:8][C:7]2[CH:10]=[CH:11][CH:12]=[C:5]([N+:2]([O-:4])=[O:3])[CH:6]=2)(=[O:18])=[O:17])[CH2:15][CH2:14]1

Participants

7

Reactant 3

HCID 8471TriethylamineHCID 2724030Benzenemethanamine, 3-nitro-, hydrochloride (1:1)HCID 2760919Cyclopropanesulfonyl chloride

Product 1

HCID 58956316HCID 58956316, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

3-Nitrobenzylamine HCl (1.48 g), cyclopropanesulfonyl chloride (1 g) and triethylamine (2.98 mL) were dissolved in dichloromethane (20 mL). The reaction solution was stirred at rt overnight. The reaction mixture was diluted with 1N HCl aq. solution (50 mL) and water (100 mL). The solution was extracted with ethyl acetate (2×100 mL). The organic solution was evaporated to give N-cyclopropylsulfonyl-3-nitrobenzylamine.

Workup

  1. extractionThe solution was extracted with ethyl acetate (2×100 mL)
  2. customThe organic solution was evaporated

Sources & evidence

ORD record
ord-577a5709776241d4adcbe8a1436bc8c4
Source dataset
uspto-grants-2015_02
Patent number
US08962643B2

Reaction notes

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