反应详情

A solution of 5 g 2-Amino-3-nitro-phenol, 4.5 g 1-Bromo-2-methoxy-ethane, 4.4 g K2CO3 in 50 mL DMF were heated to 60° C. for 16 h. Then 50 mL of water were added and the mixture was extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step. Yield: 5.8 g.

1. extractionthe mixture was extracted with ethyl acetate (3×100 ml)
2. dry with materialThe combined organic layers were dried over MgSO4
3. customthe solvents were removed under reduced pressure
4. customThe remaining product was pure enough for the next reaction step