2-Amino-5-chloropyridine → HCID 23345083, compound

HRID 1856462Notes

Reaction equation

HRID 1856462 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([NH2:21])=[N:19][CH:20]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:21][C:18]1[CH:17]=[CH:16][C:15]([Cl:14])=[CH:20][N:19]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 23345083HCID 23345083, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dichlorobenzoyl isocyanate (2.2 grams; 0.01 mole) and 5-chloro-2-aminopyridine (1.3 grams; 0.01 mole) were mixed in about 50 ml. of ethyl acetate, at room temperature, and the reaction mixture was stirred overnight (about 18 hours) at room temperature. Solvent was then evaporated, water was added, and the product was extracted with ethyl acetate. The ethyl acetate was evaporated, and the product recrystallized from ethanol, m.p., 211°-215° C. Elemental analysis showed the following:

Workup

  1. customSolvent was then evaporated
  2. additionwater was added
  3. extractionthe product was extracted with ethyl acetate
  4. customThe ethyl acetate was evaporated
  5. customthe product recrystallized from ethanol, m.p., 211°-215° C

Sources & evidence

ORD record
ord-ce78079cb0874f019466e149c0570a15
Source dataset
uspto-grants-1980_08
Patent number
US04219557

Reaction notes

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