2-Amino-5-(trifluoromethyl)pyridine → HCID 13023075, compound

HRID 1856464Notes

Reaction equation

HRID 1856464 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]([F:23])([F:14])[F:24])=[CH:21][N:20]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 13023075HCID 13023075, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dichlorobenzoyl isocyanate (1.1 grams; 0.005 mole) and 5-(trifluoromethyl)-2-aminopyridine (800 mg; 0.005 mole) were mixed in 50 ml. of ethyl acetate at room temperature and stirred overnight (about 18 hours) at room temperature. Solvent was then evaporated and the product recrystallized from ethanol, m.p. 228°-230° C., yield 200 mg. Elemental analysis showed:

Workup

  1. customSolvent was then evaporated
  2. customthe product recrystallized from ethanol, m.p. 228°-230° C., yield 200 mg

Sources & evidence

ORD record
ord-9a762a3229954e8399cac1931635a0ca
Source dataset
uspto-grants-1980_08
Patent number
US04219557

Reaction notes

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