反应详情

To a suspension of 0.1 Mol of diethyl malonate and 0.25 Mol of sodium hydride in tetrahydrofuran was added a solution of 0.1 Mol 1-bromo-3-methyl-4-nitro-2-butene in tetrahydrofuran and stirred for 3 hours at room temperature. The reaction mixture was worked up via an acid extraction with ether. The excess of diethyl malonate was cautiously removed via distillation and the product purified by column chromatography over silica gel using ether/hexane 1:1 as eluent. A yellow oil was obtained.

1. extractionThe reaction mixture was worked up via an acid extraction with ether
2. customThe excess of diethyl malonate was cautiously removed via distillation
3. customthe product purified by column chromatography over silica gel
4. customA yellow oil was obtained