Ethyl Acetate → HCID 54469756, compound

HRID 1856855Notes

Reaction equation

HRID 1856855 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([SH:22])[N:14]=[C:13]2[CH2:23][CH2:24][CH3:25])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.[H-].[Na+].[Cl-].[NH4+].[C:30]([O:33][CH2:34][CH3:35])(=[O:32])[CH3:31]>>[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([S:22][CH:2]3[CH2:3][CH2:4][C:5](=[CH:31][C:30]([O:33][CH2:34][CH3:35])=[O:32])[CH2:6][CH2:10]3)[N:14]=[C:13]2[CH2:23][CH2:24][CH3:25])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1

Participants

5

Reactant 4

HCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 19609113HCID 19609113, compound

Product 1

HCID 54469756HCID 54469756, compound

Procedure

1.1 g of the product obtained in Stage 6 of Example 1 is introduced, 127 mg of a suspension of sodium hydride at 50% in oil is added and the reaction medium is left under agitation for 15 minutes at ambient temperature. Then 657 mg of the product obtained in Stage 1 of Preparation 1 is added and the reaction medium is left under agitation for 24 hours at ambient temperature, followed by hydrolysis with a saturated solution of ammonium chloride and extraction with ethyl acetate and after chromatography, 880 mg of the expected product (amorphous solid) is obtained.

Workup

  1. additionis added
  2. waitthe reaction medium is left under agitation for 24 hours at ambient temperature

Sources & evidence

ORD record
ord-cd46802a85d648598698286bc774d0da
Source dataset
uspto-grants-2000_11
Patent number
US06143774

Reaction notes

Loading…