6-Hydroxyquinoline → 6,7-Dimethoxy-4-(6-quinolyloxy)quinoline

HRID 1857103Notes

Reaction equation

HRID 1857103 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2

Participants

3

Reactant 2

HCID 113746-HydroxyquinolineHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 221326276,7-Dimethoxy-4-(6-quinolyloxy)quinolineYield 46.4%

Procedure

Using 4-chloro-6,7-dimethoxyquinoline (90 mg) and commercially available 6-hydroxyquinoline (176 mg), reaction and purification were carried out in the same manner as described in Example 8 to obtain 62 mg of the title compound (yield: 46%).

Sources & evidence

ORD record
ord-fef598185b944baaa1006a5356bc405e
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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