Ethyl Bromide → Ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate

Temperature

55 °C

A mixed solution of 1-bromo-2-(1-ethoxyethyl)oxymethylbenzene (3.11 g, 0.012 mol) and dry THF (10 ml) was added dropwise at 50 to 60° C. over 25 minutes to a solution prepared by adding dry THF (2 ml) and ethyl bromide (0.2 ml) to magnesium (0.44 g, 0.018 mol) in a stream of nitrogen. After completion of the addition, the mixture was stirred at 50 to 60° C. for 1 hour and cooled to room temperature. After cooling, the mixture was added dropwise to a mixed solution of ethyl oxalate (2.63 g, 0.018 mol) and dry THF (30 ml) at below -50° C. over 15 minutes. Then, the mixture was stirred at -50 to -60° C for 1 hour. After completion of the reaction, water (200 ml) was added, and the mixture was extracted with ether (200 ml). The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain ethyl 2-[2-{(1-ethoxyethyl)oxymethyl}phenyl]-2-oxoacetate (2.30 g, Yield: 68.4%) as a colorless oil.

1. customprepared
2. additionAfter completion of the addition
3. temperaturecooled to room temperature
4. temperatureAfter cooling
5. stirringThen, the mixture was stirred at -50 to -60° C for 1 hour
6. additionwas added
7. extractionthe mixture was extracted with ether (200 ml)
8. dry with materialThe extract was dried over anhydrous magnesium sulfate
9. concentrationconcentrated under reduced pressure
10. customThe resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane)

ORD record

ord-0a105e18b7134ab89133823d5fdef14e

Source dataset

uspto-grants-2000_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06147231