Potassium Phosphate, Dibasic → HCID 9881623, compound

HRID 1857975Notes

Reaction equation

HRID 1857975 reaction equation
Br[C:2]1[S:6][C:5]([NH2:7])=[N:4][N:3]=1.OP([O-])([O-])=O.[K+].[K+].[C:15]([NH:22][CH2:23][CH2:24][NH2:25])([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>CN(C=O)C>[NH2:7][C:5]1[S:6][C:2]([NH:25][CH2:24][CH2:23][NH:22][C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[N:3][N:4]=1

Participants

5

Reactant 3

HCID 24450Potassium Phosphate, DibasicHCID 187201N-BOC-ethylenediamineHCID 36508832-Amino-5-bromo-1,3,4-thiadiazole

Product 1

HCID 9881623HCID 9881623, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-bromo-1,3,4-thiadiazol-2-ylamine (5.40 g), K2HPO4 (7.84 g), and Boc-ethylenediamine (9.6 g) in 20 ml of DMF is stirred at ambient temperature for 18 hours. The solid paste obtained is recrystallized from 100 ml of acetonitrile and 100 ml of water to provide 6.18 g (79%) of the title compound.

Workup

  1. customThe solid paste obtained
  2. customis recrystallized from 100 ml of acetonitrile and 100 ml of water

Sources & evidence

ORD record
ord-9b96220e0f0a44ddbe0100e42b9aadf4
Source dataset
uspto-grants-2000_11
Patent number
US06150385

Reaction notes

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