反应详情

温度

80 °C

6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-[3-(3,3-dimethyl-but-1-ynyl)-phenyl]-1-methyl-1H-quinolin-2-one (330 mg, 0.633 mMol) was dissolved in 4 mL of thionyl chloride and stirred at ambient temperature under a stream of dry N2 for 2 hours. The reaction mixture was then concentrated under vacuum and toluene (5 mL) was added to the reaction mixture which was subsequently concentrated under vacuum to give a yellow solid. 210 mg of the yellow solid was dissolved in 5.0 mL of anhydrous DMF under an atmosphere of dry N2. To this solution was added 800 mg of potassium carbonate and 300 mg of 1,2,4-triazole and the reaction mixture was subsequently heated to 80° C. and stirred overnight at this temperature. The reaction mixture was then concentrated under vacuum and partitioned between EtOAc and water. The EtOAc layer was washed 3 more times with water and then with brine. The EtOAc layer was then dried over Na2SO4, filtered and concentrated under vacuum to give a yellow solid. The solid was chromatographed on flash silica gel eluting with a gradient of MeOH/DCM/NH4OH (2/98/0.1) to MeOH/DCM/NH4OH (7/93/0.1) to give 150 mg of the titled product as a white solid.

1. concentrationThe reaction mixture was then concentrated under vacuum and toluene (5 mL)
2. additionwas added to the reaction mixture which
3. concentrationwas subsequently concentrated under vacuum
4. customto give a yellow solid
5. concentrationThe reaction mixture was then concentrated under vacuum
6. custompartitioned between EtOAc and water
7. washThe EtOAc layer was washed 3 more times with water
8. dry with materialThe EtOAc layer was then dried over Na2SO4
9. filtrationfiltered
10. concentrationconcentrated under vacuum
11. customto give a yellow solid
12. customThe solid was chromatographed on flash silica gel eluting with a gradient of MeOH/DCM/NH4OH (2/98/0.1) to MeOH/DCM/NH4OH (7/93/0.1)