反应详情

A solution of 8.04 g (67 mmol) of 4-cyanophenol in 100 ml of xylene was treated with a solution of 2.99 g (74 mmol) of sodium hydroxide in 20 ml of water and the mixture was stirred for 30 minutes. To this mixture were added 13.88 g (100 mmol) of potassium carbonate and 12.83 g (75 mmol) of 2-diethylaminoethyl chloride hydrochloride. The resulting mixture was then heated at reflux for 3 hours, subsequently left to cool, washed twice with 50 ml of water each time, dried over magnesium sulfate, filtered and evaporated to give 10.93 g (74%) of 4-(2-diethylaminoethoxy)benzonitrile as a colorless mobile liquid.

1. temperatureThe resulting mixture was then heated
2. temperatureat reflux for 3 hours
3. waitsubsequently left
4. temperatureto cool
5. washwashed twice with 50 ml of water each time
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. customevaporated