Ammonium Hydroxide → HCID 22123263, compound

HRID 1859202Notes

Reaction equation

HRID 1859202 reaction equation
[N:1]([CH2:4][C:5]1[N:10]=[C:9]([CH2:11][N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]([C:21]3[C:22](=O)[O:23][C:24](=[O:36])[C:25]=3[C:26]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[N:28]([CH3:35])[CH:27]=3)=[CH:13]2)[CH:8]=[CH:7][CH:6]=1)=[N+:2]=[N-:3].[OH-].[NH4+:39]>CN(C)C=O>[N:1]([CH2:4][C:5]1[N:10]=[C:9]([CH2:11][N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]([C:21]3[C:22](=[O:23])[NH:39][C:24](=[O:36])[C:25]=3[C:26]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[N:28]([CH3:35])[CH:27]=3)=[CH:13]2)[CH:8]=[CH:7][CH:6]=1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 22123300HCID 22123300, compound

Product 1

HCID 22123263HCID 22123263, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product from step b) was heated with ammonium hydroxide (5 mL) and dimethylformamide (5 mL) at 75° C. for 5 h in a sealed flask. The flask was cooled and the content partitioned between ethyl acetate and water. The organic phase was washed with ammonium hydroxide. Evaporation afforded 188 mg of the sub-title product, which was used without further purification.

Workup

  1. temperatureThe flask was cooled
  2. customthe content partitioned between ethyl acetate and water
  3. washThe organic phase was washed with ammonium hydroxide
  4. customEvaporation

Sources & evidence

ORD record
ord-08eb542c40114b818594b98da8549975
Source dataset
uspto-grants-2000_11
Patent number
US06153641

Reaction notes

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