Diethyl methylmalonate → HCID 18625691, compound

HRID 1859977Notes

Reaction equation

HRID 1859977 reaction equation
[CH3:1][CH:2]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:13]1([CH2:19][CH2:20][CH2:21]Br)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[H-].[Na+]>>[CH3:1][C:2]([CH2:21][CH2:20][CH2:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

4

Reactant 3

HCID 11857Diethyl methylmalonateHCID 12503(3-Bromopropyl)benzeneHCID 24758Sodium hydride

Product 1

HCID 18625691HCID 18625691, compoundYield 79.3%

Procedure

In a similar manner to that described in Reference example 2(a), a reaction was carried out using diethyl 2-methylmalonate (3.48 g), 3-phenylpropyl bromide (3.98 g) and sodium hydride (55% suspension in oil, 0.96 g) and the reaction mixture was treated to afford the desired compound (4.63 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-648244b233894a03849f93b1c2f85088
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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