Potassium Carbonate → HCID 18625866, compound

HRID 1859981Notes

Reaction equation

HRID 1859981 reaction equation
[OH:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][C:7]([CH3:22])([CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.Br[CH2:26][CH2:27][O:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][O:30]1.C(=O)([O-])[O-].[K+].[K+]>CC(N(C)C)=O>[CH3:22][C:7]([CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([CH2:6][C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:26][CH2:27][O:28][CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][O:30]2)=[CH:24][CH:23]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 18625714HCID 18625714, compound

Product 1

HCID 18625866HCID 18625866, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a similar manner to that described in Reference example 3(e), a reaction was carried out using ethyl 2-(4-hydroxybenzyl)-2-methyl-5-phenylvalerate (1.58 g), which is the product of Reference example 7(d), 2-(2-bromoethoxy)tetrahydropyran (0.94 g) and potassium carbonate (1.86 g) in dimethylacetamide and the reaction mixture was treated to afford the desired compound (1.64 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-d00c92a6152f4cffbb12f84b4794e06a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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