Potassium Carbonate → HCID 18625731, compound

HRID 1859995Notes

Reaction equation

HRID 1859995 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:16][C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=2)([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.Br[CH2:27][CH2:28][O:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][O:31]1.C(=O)([O-])[O-].[K+].[K+]>CC(N(C)C)=O>[CH:23]([C:20]1[CH:19]=[CH:18][C:17]([O:16][C:9]([CH3:15])([CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:27][CH2:28][O:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][O:31]3)=[CH:3][CH:4]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:22][CH:21]=1)([CH3:24])[CH3:25]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 18626008HCID 18626008, compound

Product 1

HCID 18625731HCID 18625731, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a similar manner to that described in Reference example 3(e), a reaction was carried out using ethyl 3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)-2-methylpropionate (1.00 g), which is the product of Reference example 9(b), 2-(2-bromoethoxy)tetrahydropyran (1.84 g) and potassium carbonate (1.62 g) in dimethylacetamide and the reaction mixture was treated to afford the desired compound (1.06 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-bf1cb956fe5d4b73aecd88797835796b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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