Hydrogen Bromide → HCID 18625758, compound

HRID 1860077Notes

Reaction equation

HRID 1860077 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1.Br.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]([F:31])([F:32])[F:33])=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 11430Potassium CarbonateHCID 18626025HCID 18626025, compound

Product 1

HCID 18625758HCID 18625758, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In a similar manner to that described in Reference example 37(b), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-(4-trifluoromethoxyphenoxy)propionate (4.08 g), which is the product of Reference example 40(a), a solution of hydrogen bromide in acetic acid (25%, 40 ml) and potassium carbonate (1.68 g) and the reaction mixture was treated to afford the desired compound (2.98 g) as a colorless oil.

Sources & evidence

ORD record
ord-4abd936878844e01b2409fe2b5c27cf0
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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