Triethylamine → HCID 178443962, compound

HRID 1860434Notes

Reaction equation

HRID 1860434 reaction equation
Cl[C:2]1[NH:7][CH:6]([CH3:8])[N:5]=[C:4]2[N:9]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=3[CH3:25])[C:10]([CH3:16])=[C:11]([C:12](=[O:15])[CH2:13][Cl:14])[C:3]=12.[NH2:26][CH:27]([CH2:31][CH2:32][CH3:33])[CH2:28][CH2:29][CH3:30].C(N(CC)CC)C>C(OCC)(=O)C>[CH3:30][CH2:29][CH2:28][CH:27]([NH:26][C:2]1[NH:7][CH:6]([CH3:8])[N:5]=[C:4]2[N:9]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][C:18]=3[CH3:25])[C:10]([CH3:16])=[C:11]([C:12](=[O:15])[CH2:13][Cl:14])[C:3]=12)[CH2:31][CH2:32][CH3:33]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 386654-HeptanamineHCID 178425446HCID 178425446, compound

Product 1

HCID 178443962HCID 178443962, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of compound (7) (730 mg, 2 mmol), 4-aminoheptane (250 mg, 2.2 mmol) and triethylamine (250 mg, 2.5 mmol) were stirred at ambient temperature for 16 hours. The solution was diluted with ethyl acetate and washed with brine. The organic layer was dried over sodium sulfate and evaporated to dryness to provide compound (8).

Workup

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-90aea66c5880495d84efb12c30174953
Source dataset
uspto-grants-2003_03
Patent number
US06531475B1

Reaction notes

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