反应详情

温度

50 °C

To a solution of carbonic acid 4-nitro-phenyl ester 2-trimethylsilanyl-ethyl ester (566 mg, 2 mmol) in DMF (4 ml) at 23° C. under an atmosphere of argon was added DMAP (12 mg, 0.1 mmol), DIEA (0.35 ml, 2 mmol) and 4-fluoro-6-methyl-benzene-1,3-diamine. The resulting solution was heated to 50° C. for 48 h. The reaction mixture was quenched with saturated NaCHO3 (aq), extracted with EtOAc (3×20 ml). The EtOAc was removed in-vacuo, and the residue was re-dissolved in Et2O then washed with 3 N NaOH (aq), water, brine, dried with Na2SO4, filtered and concentrated. Purification by silica gel chromatography (2:8-7:3 ethyl acetate-hexane) gave (5-amino-4-fluoro-2-methyl-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester (160 mg, 28%). MS (ESI+) [M+H]/z Calc'd 634, found 634.

1. customThe reaction mixture was quenched with saturated NaCHO3 (aq)
2. extractionextracted with EtOAc (3×20 ml)
3. customThe EtOAc was removed in-vacuo
4. dissolutionthe residue was re-dissolved in Et2O
5. washthen washed with 3 N NaOH (aq), water, brine
6. dry with materialdried with Na2SO4
7. filtrationfiltered
8. concentrationconcentrated
9. customPurification by silica gel chromatography (2:8-7:3 ethyl acetate-hexane)