Hydrochloric Acid → HCID 86758878, compound

HRID 1861663Notes

Reaction equation

HRID 1861663 reaction equation
[C:1]([S:4][CH2:5][CH2:6][N:7]([CH2:19][CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:8]([NH:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:9])(=[O:3])[CH3:2].[ClH:27]>CCOCC.C(OCC)(=O)C>[ClH:27].[C:1]([S:4][CH2:5][CH2:6][N:7]([CH2:19][CH2:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1)[C:8]([NH:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:9])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9821409HCID 9821409, compound2×

Product 1

HCID 86758878HCID 86758878, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-[2-(acetylthio) ethyl]-1-(2-cyclohexylethyl)-3-[2-(1-piperidyl) ethyl] urea (Compound 3-1, 618 mg) in ether, there was added a 4N hydrogen chloride solution in ethyl acetate (0.4 ml). The resulting precipitates were filtered off to give the title compound (Compound 6-1, 401 mg) in the form of crystals.

Workup

  1. customThe resulting precipitates
  2. filtrationwere filtered off

Sources & evidence

ORD record
ord-38d774eace6e4f10b65c28fe1f8ef40d
Source dataset
uspto-grants-2003_03
Patent number
US06534499B2

Reaction notes

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