反应详情

In the process for preparing crystalline disodium pamidronate from the reaction solution of neutralization of pamidronic acid with an organic sodium compound according to the second method, it is characterized to be included the process which pamidronic acid is neutralized with sodium methoxide or sodium ethoxide in absolute methanol or absolute ethanol under refluxing: the salt produced from neutralization is dissolved in water and the insoluble materials produced are filtered: the filtrate is allowed to stand at room temperature to induce crystallization: the resulting solution is slowly cooled and filtered to obtain the crystals: and then the resulting crystals are dried at temperature of 75˜85° C. under normal pressure to obtain the crystalline disodium pamidronate hydrate.

1. temperatureunder refluxing
2. customthe salt produced from neutralization
3. customthe insoluble materials produced
4. filtrationare filtered
5. customto stand at room temperature
6. customcrystallization
7. temperaturethe resulting solution is slowly cooled
8. filtrationfiltered
9. customto obtain the crystals
10. customthe resulting crystals are dried at temperature of 75˜85° C. under normal pressure