3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1863577Notes

Reaction equation

HRID 1863577 reaction equation
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>C1CCC2=NCCCN2CC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CS(=O)(=O)[O-].CS(C)=O.Nc1ccccc1-c1ccccc1.[Pd]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Participants

6

Reactant 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Product 1

HCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 131675802HCID 131675802, compoundCatalystHCID 679Dimethyl SulfoxideSolvent4×

Workup

  1. additionsolution of bipheny (3%) and acetic acid to quench reaction. Acetic acid amount not specified.
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-eb1fdc050f8e4c7da30b1b6e9b9ae88d
Source dataset
Pd-catalyzed Buchwald-Hartwig C-N cross-coupling
Original link
View source

Reaction notes

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