Sodium Iodide → 1-(2-Chloro-benzenesulfonyl)-3-isopropyl-4-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

HRID 1864456Notes

Reaction equation

HRID 1864456 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N@:11]1[CH2:13][CH:12]1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:18][CH2:17]1)=[O:15])(=[O:10])=[O:9].[I-].[Na+].[CH:34]([N:37]=[C:38]=[O:39])([CH3:36])[CH3:35]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:13][CH:12]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([C:28]([F:30])([F:29])[F:31])=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])[N:37]([CH:34]([CH3:36])[CH3:35])[C:38]1=[O:39])(=[O:9])=[O:10]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 61277Isopropyl isocyanateHCID 178519786HCID 178519786, compound

Product 1

HCID 671411111-(2-Chloro-benzenesulfonyl)-3-isopropyl-4-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one

Procedure

In analogy to example 2, [(S)-1-(2-chloro-benzenesulfonyl)-aziridin-2-yl]-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-methanone (example 72, step 3) was reacted with sodium iodide and isopropylisocyanate to give the title compound as a colorless foam. MS: 560.2 ([M+H]+)

Sources & evidence

ORD record
ord-13a12e0a583a48baba58076ea951831a
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

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