Hydrochloric Acid → HCID 59258281, compound

HRID 1864628Notes

Reaction equation

HRID 1864628 reaction equation
[Li+].[OH-].[O:3]=[C:4]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C@H:20]([CH2:41][C:42]3[CH:51]=[C:50]([CH3:52])[C:45]4[NH:46][C:47](=[O:49])[O:48][C:44]=4[CH:43]=3)[C:21]([N:23]3[CH2:28][CH2:27][CH:26]([CH:29]4[CH2:34][CH2:33][N:32]([CH2:35][C:36]([O:38]CC)=[O:37])[CH2:31][CH2:30]4)[CH2:25][CH2:24]3)=[O:22])=[O:18])[CH2:13][CH2:12]2)[CH2:9][CH2:8][C:7]2[CH:53]=[CH:54][CH:55]=[CH:56][C:6]=2[NH:5]1.Cl>O.C1COCC1>[O:3]=[C:4]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C@H:20]([CH2:41][C:42]3[CH:51]=[C:50]([CH3:52])[C:45]4[NH:46][C:47](=[O:49])[O:48][C:44]=4[CH:43]=3)[C:21]([N:23]3[CH2:28][CH2:27][CH:26]([CH:29]4[CH2:34][CH2:33][N:32]([CH2:35][C:36]([OH:38])=[O:37])[CH2:31][CH2:30]4)[CH2:25][CH2:24]3)=[O:22])=[O:18])[CH2:13][CH2:12]2)[CH2:9][CH2:8][C:7]2[CH:53]=[CH:54][CH:55]=[CH:56][C:6]=2[NH:5]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59257949HCID 59257949, compound

Product 1

HCID 59258281HCID 59258281, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 39 mg (1.61 mmol) LiOH in 5 mL water was added to a solution of 240 mg (0.32 mmol) (R)-2-(1′-ethoxycarbonylmethyl-4,4′-bipiperidinyl-1-yl)-1-(4-methyl-2-oxo-2,3-dihydrobenzoxazol-6-ylmethyl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 10 mL THF and the reaction solution was stirred for 1 h at RT. 1.61 mL of 1 M HCl was added and the mixture was evaporated down i.vac. The residue was combined with a little water, stirred, the water was decanted off and the residue was dried in the air.

Workup

  1. customthe mixture was evaporated down i.vac
  2. stirringstirred
  3. customthe water was decanted off
  4. customthe residue was dried in the air

Sources & evidence

ORD record
ord-f2a241f55ced48eeb65633899a9b83e4
Source dataset
uspto-grants-2009_12
Patent number
US07625886B2

Reaction notes

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