反应详情

A solution of 0.10 g (4.18 mmol) LiOH in 6 mL water was added to a solution of 0.98 g (1.83 mmol) (R)-1-methoxycarbonyl-2-(2-methoxy-7-methyl-1H-benzimidazol-5-yl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 18 mL THF and the reaction solution was stirred overnight at RT. 1.05 mL of 4 M HCl was added and the THF was eliminated i.vac. The mixture was decanted to separate off the oily residue, this was dissolved in DCM/MeOH and the organic phase was dried on Na2SO4. After the desiccant and solvent had been eliminated the desired product was obtained.

1. customThe mixture was decanted
2. customto separate off the oily residue
3. dissolutionthis was dissolved in DCM/MeOH
4. customthe organic phase was dried on Na2SO4
5. customwas obtained