反应详情

温度

100 °C

80 g of 3-quinoline carboxaldehyde, 85 g of malonic acid and 6.50 g of piperidine were added to 350 ml of pyridine, and stirred at 100° C. for 3 hours. After mixing with 1000 ml of distilled water, concentrated HCl was added thereto until pH of the solution became 4.8, and stirred for 1 hour. The resulting solid was filtrated under a reduced pressure, washed with 1500 ml of distilled water, and dried for 15 to 40 hours to obtain 96 g of the title compound as a white solid (yield 95%).

1. additionwas added
2. stirringstirred for 1 hour
3. filtrationThe resulting solid was filtrated under a reduced pressure
4. washwashed with 1500 ml of distilled water
5. customdried for 15 to 40 hours