反应详情

温度

100 °C

1-Fluoro-4-nitro-benzene (80.2 g, 0.57 mmol) is dissolved in DMF (550 mL) and to that solution is added K2CO3 (157.0 g, 1.14 mmol). To that solution is added 4-(1H-imidazol-2-yl)-pyridine (55.0 g, 0.38 mmol) and the reaction is heated at 100° C. for 18 h. The solution is then cooled to RT and EtOAc (1.5 L) and water (2.0 L) are then added and the suspension is vacuum filtered. The resulting solid was then purified by column chromatography (EtOAc) to afford 4-[1-(4-nitro-phenyl)-1H-imidazol-2-yl]-pyridine as a brown solid.

1. temperatureThe solution is then cooled to RT
2. filtrationfiltered
3. customThe resulting solid was then purified by column chromatography (EtOAc)