Hydrochloric Acid → HCID 57974041, compound

HRID 1864852Notes

Reaction equation

HRID 1864852 reaction equation
[CH3:1][C@H:2]1[N:7]([CH3:8])[CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]([CH2:15][C:16]([O:18]C)=[O:17])[C:3]1=[O:20].[Li+:21].[OH-].Cl>C1COCC1>[CH3:1][C@H:2]1[N:7]([CH3:8])[CH2:6][CH:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]([CH2:15][C:16]([O-:18])=[O:17])[C:3]1=[O:20].[Li+:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86616393HCID 86616393, compound

Product 1

HCID 57974041HCID 57974041, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl [(3R)-3,4-dimethyl-2-oxo-6-phenylpiperazin-1-yl]acetate from Step B (50 mg, 0.18 mmol) in THF (1 mL) was added 1 N aqueous LiOH (0.20 mL, 0.20 mmol) and the resulting mixture was stirred at ambient temperature for 4 h. The mixture was adjusted to pH 6 by addition of 1 N HCl and concentrated to dryness in vacuo to give the title compound. MS: m/z=263 (M+1).

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-372b83d36f67475297258b3bd8fe92f0
Source dataset
uspto-grants-2009_12
Patent number
US07625901B2

Reaction notes

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