Hydrochloric Acid → HCID 66973356, compound

HRID 1864893Notes

Reaction equation

HRID 1864893 reaction equation
C(OC([NH:8][C:9]1([CH2:20][NH:21][C:22]2([C:27]([O:29][CH3:30])=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23]2)[C:17]2[C:12](=[C:13]([F:19])[CH:14]=[C:15]([F:18])[CH:16]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:31]>CCOC(C)=O>[ClH:31].[NH2:8][C:9]1([CH2:20][NH:21][C:22]2([C:27]([O:29][CH3:30])=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23]2)[C:17]2[C:12](=[C:13]([F:19])[CH:14]=[C:15]([F:18])[CH:16]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66973000HCID 66973000, compound

Product 1

HCID 66973356HCID 66973356, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of methyl 1-[({1-[(tert-butoxycarbonyl)amino]-4,6-difluoro-2,3-dihydro-1H-inden-1-yl}methyl)amino]cyclopentanecarboxylate from Step G (753 mg, 1.77 mmol) in EtOAc (40 mL) at 0° C. was saturated with HCl (g). The reaction mixture was aged at 0° C. for 45 min then concentrated in vacuo to give the title compound. MS: m/z=325 (M+1).

Workup

  1. customat 0° C.
  2. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-155281df4ec84a1db4afeef6efeb96bf
Source dataset
uspto-grants-2009_12
Patent number
US07625901B2

Reaction notes

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