反应详情

To an oven dried, nitrogen flushed 100 ml round bottom flask was added 5-hydroxyoxindole (10 mmol), 1-(2-methoxyethyl)-piperidin-4-ol (11 mmol), triphenylphosphine (15 mmol), Anhydrous tetrahydrofuran (35 ml) and a stirrer bar. Diethyl azodicarboxylate (15 mmol) was added slowly to the mixture and stirred at room temperature overnight. The reaction was concentrated in vacuo and flash chromatography (silica, 5% methanol in ethyl acetate). Upon concentration a reddish oil (470 mg) was obtained with a 75% purity by H-NMR and LC/MS.

1. customTo an oven dried
2. customnitrogen flushed 100 ml round bottom flask
3. concentrationThe reaction was concentrated in vacuo and flash chromatography (silica, 5% methanol in ethyl acetate)
4. concentrationUpon concentration a reddish oil (470 mg)
5. customwas obtained with a 75% purity by H-NMR and LC/MS