Piperidine → HCID 10583457, compound

HRID 1865386Notes

Reaction equation

HRID 1865386 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][O:9][C:10](Cl)=[O:11]>CCCCCC.C(OCC)(=O)C>[Cl:7][CH2:8][O:9][C:10]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:11]

Participants

5

Reactant 2

HCID 8082PiperidineHCID 62754Chloromethyl chloroformate

Product 1

HCID 10583457HCID 10583457, compoundYield 89.6%

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

Piperidine(1.06 g, 12.5 mmol) was added to a solution of chloroformic acid chloromethyl ester(645 mg, 5 mmol) in n-hexane (15 mL) at 0° C. under argon atmosphere, and the mixture was stirred at the same temperature for 30 minutes. The reaction mixture was diluted with ethyl acetate. After the ethyl acetate solution was washed successively with 1N hydrochloric acid(20 mL), water and brine, dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to give the title compound(796 mg, 89.6%) as a colorless oil.

Workup

  1. washAfter the ethyl acetate solution was washed successively with 1N hydrochloric acid(20 mL), water and brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9978b3b9a885495ea6755ba3e83176ef
Source dataset
uspto-grants-2009_12
Patent number
US07626042B2

Reaction notes

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