反应详情

A mixture of salicylic acid (6.90 g, 50 mmol), 2,5-bis(trifluoromethyl)-aniline (11.46 g, 50 mmol), phosphorus trichloride(2.18 ml, 25 mmol) and chlorobenzene(150 mL) was refluxed for 4 hours. After the reaction mixture was cooled to room temperature, it was diluted with ethyl acetate. The organic layer was washed with water and brine, and dried over magnesium sulfate. The residue obtained by evaporation of the solvent under reduced pressure was washed with n-hexane to give the title compound(8.4 g, 47.8%) as a white solid.

1. temperaturewas refluxed for 4 hours
2. washThe organic layer was washed with water and brine
3. dry with materialdried over magnesium sulfate
4. customThe residue obtained by evaporation of the solvent under reduced pressure
5. washwas washed with n-hexane