Acetonitrile → 4-Phenyl-1-(4-phenylbutyl)piperidine

HRID 1866066Notes

Reaction equation

HRID 1866066 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])([O-])=O.[K+].[K+].[C:19](#N)[CH3:20]>>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([CH2:12][CH2:7][CH2:8][CH2:9][C:20]3[CH:19]=[CH:3][CH:2]=[CH:1][CH:6]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 698734-Phenylpiperidine

Product 1

HCID 30356724-Phenyl-1-(4-phenylbutyl)piperidine

Procedure

4-Phenylpiperidine (1 eq) was reacted with 4-phenylbromobutyl (1 eq) in the presence of K2CO3 in acetonitrile at reflux overnight. The product obtained was treated and purified on a silica column. The 1H NMR at 500 MHz is in accordance with the expected structure.

Workup

  1. temperatureat reflux overnight
  2. customThe product obtained
  3. additionwas treated
  4. custompurified on a silica column

Sources & evidence

ORD record
ord-793b3f195d3042fe9748f4524731fa35
Source dataset
uspto-grants-2009_12
Patent number
US07629359B2

Reaction notes

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