Hydrochloric Acid → HCID 57974120, compound

HRID 1866644Notes

Reaction equation

HRID 1866644 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:12]([CH3:23])([CH3:22])[C:11](=[O:24])[N:10]2[CH2:25][C:26]([O:28]CC)=[O:27])[CH:5]=[C:6]([F:8])[CH:7]=1.[Li+:31].[OH-].Cl>C1COCC1.O>[C:18]([O:17][C:15]([N:13]1[CH2:14][C@@H:9]([C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=2)[N:10]([CH2:25][C:26]([O-:28])=[O:27])[C:11](=[O:24])[C:12]1([CH3:23])[CH3:22])=[O:16])([CH3:21])([CH3:19])[CH3:20].[Li+:31]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 66973509HCID 66973509, compound

Product 1

HCID 57974120HCID 57974120, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tert-butyl (5R)-5-(3,5-difluorophenyl)-4-(2-ethoxy-2-oxoethyl)-2,2-dimethyl-3-oxopiperazine-1-carboxylate from Step C (1.18 g, 2.77 mmol) in THF (18 mL) and H2O (2 mL) was added 1 N aqueous LiOH (3.04 mL, 3.04 mmol) and the resulting mixture was stirred at ambient temperature for 5 h. The mixture was adjusted to pH 6 by addition of 1 N HCl and concentrated to dryness in vacuo to give the title compound. MS: m/z=343 (M−C4H7).

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-3d7efa451c8d4f04aa734418805885b8
Source dataset
uspto-grants-2009_12
Patent number
US07629338B2

Reaction notes

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