Sodium hydride → HCID 57974043, compound

To a stirred solution of (±)-6-phenylpiperidin-2-one (155 mg, 0.885 mmol) in THF (10 mL), cooled to 0° C., was added NaH (30.0 mg, 1.24 mmol). The ice bath was removed and the reaction was allowed to warm to ambient temperature. After 1 h at ambient temperature, the reaction was cooled to 0° C. prior to the introduction of methyl bromoacetate (149 mg, 0.973 mmol). After 40 minutes, the ice bath was removed and the reaction was stirred under nitrogen for 12 h. Additional quantities of NaH and methyl bromoacetate were then added in parts to nearly consume the lactam, as judged by LCMS analysis. After sufficient lactam was consumed, 1 M aqueous sodium hydroxide was added (1 mL, 1 mmol). After a majority of the methyl ester was saponified (˜3 h), the reaction was quenched with 1 M hydrochloric acid (5 mL), and EtOAc (50 mL). The organics were washed with saturated brine (twice), dried over sodium sulfate, filtered and concentrated in vacuo, to yield a residue which was used without further purification. MS: m/z=234 (M+1).

1. customThe ice bath was removed
2. temperaturethe reaction was cooled to 0° C.
3. waitAfter 40 minutes
4. customthe ice bath was removed
5. additionAdditional quantities of NaH and methyl bromoacetate were then added in parts
6. customto nearly consume the lactam
7. customAfter sufficient lactam was consumed
8. addition1 M aqueous sodium hydroxide was added (1 mL, 1 mmol)
9. custom(˜3 h)
10. customthe reaction was quenched with 1 M hydrochloric acid (5 mL), and EtOAc (50 mL)
11. washThe organics were washed with saturated brine (twice),
12. dry with materialdried over sodium sulfate
13. filtrationfiltered
14. concentrationconcentrated in vacuo
15. customto yield a residue which
16. customwas used without further purification

ORD record

ord-c24f4c28a84646a38d4c48c5174d3305

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07629338B2