Methylamine → HCID 69072740, compound

HRID 1867536Notes

Reaction equation

HRID 1867536 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[CH2:13][O:12][C:11]2=[O:16])=[CH:4][CH:3]=1.[CH3:17][NH2:18]>O1CCCC1.C(OC(C)C)(C)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][C:11](=[O:16])[O:12][CH2:13][C:14]([NH:18][CH3:17])=[O:15])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 675289483-[2-(4-Bromophenyl)ethyl]-1,3-oxazolidine-2,4-dione

Product 1

HCID 69072740HCID 69072740, compoundYield 90.2%

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

The procedure described in Example 2 (step 2.2.) is repeated. Starting from 2.6 g (9.15 mmol) of 3-[2-(4-bromophenyl)ethyl]-1,3-oxazolidine-2,4-dione, prepared in Example 3 (step 3.1.), and 18.3 ml (36.6 mmol) of methylamine (2M) in tetrahydrofuran, and after the product has been taken up in diisopropyl ether, 2.6 g of pure product are obtained in the form of a white solid.

Sources & evidence

ORD record
ord-1d645575ca654a6f8b0623a5c60443c3
Source dataset
uspto-grants-2009_12
Patent number
US07632850B2

Reaction notes

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