反应详情

Procedure D′: To a microwave reactor vessel, add 2-(4-Chloro-phenyl)-5-methyl-[1,3,4]oxadiazole (1.0 mmol; CAS(22815-98-1), (2-(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone (See Intermediate Preparation 23) (2.5 mmol), palladium (II) acetate (0.025 mmol), tricyclohexylphosphine (0.05 mmol), potassium carbonate (5.0 mmol) and ethanol (0.10M). Run the reaction in a CEM microwave reactor for four hours at 90° C. with 80 W power and cooling. After this time, wash the reaction with 1N hydrochloric acid while extracting with dichloromethane. Dry the organics with sodium sulfate, decant and concentrate in vacuo. Purify the title compound via radial chromatography eluting with 2M ammonia in methanol and dichloromethane. MS (m/e): 417.3 (M+1)

1. customthe reaction in a CEM microwave reactor for four hours at 90° C. with 80 W power
2. temperaturecooling
3. washAfter this time, wash
4. customthe reaction with 1N hydrochloric acid
5. extractionwhile extracting with dichloromethane
6. dry with materialDry the organics with sodium sulfate
7. customdecant
8. concentrationconcentrate in vacuo
9. customPurify the title compound via radial chromatography
10. washeluting with 2M ammonia in methanol and dichloromethane