4-Hydroxybenzaldehyde → HCID 23078883, compound

To a solution of 4-hydroxybenzaldehyde (2.44 g) in N,N-dimethylformamide (20 mL) were added cesium carbonate (7.17 g), benzyl 3-bromopropyl ether (4.81 g) and a catalytic amount of sodium iodide, and the mixture was stirred at room temperature for 4 days. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 4-(3-benzyloxypropoxy)benzaldehyde. This material was dissolved in ethanol (20 mL). To the solution was added sodium borohydride (757 mg), and the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added methanol, and the resulting mixture was concentrated under reduced pressure. Water was added to the residue, and the mixture was extracted with diethyl ether. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=5/1-2/1) to give the title compound (5.17 g).

1. extractionthe resulting mixture was extracted with diethyl ether
2. washThe organic layer was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed under reduced pressure

ORD record

ord-07854ab0dd9948d3af0921559c42590f

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07635684B2