反应详情

温度

160 °C

To a suspension of 1-(4-n-Octyloxyphenyl)piperazine (1 g)and potassium carbonate (0.476 g) in N,N-dimethylformamide (1 ml) was added p-fluorobenzonitrile (0.347 g), and stirred for 5 hours at 160° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-(4-n-Octyloxyphenyl)piperazine-1-yl]benzonitrile (0.93 g).

1. dry with materialdried over magnesium sulfate
2. filtrationThe magnesium sulfate was filtered off
3. customthe filtrate was evaporated under reduced pressure