Sodium Bicarbonate → HCID 24961262, compound

HRID 1873610Notes

Reaction equation

HRID 1873610 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:5]([C:16]#[N:17])=[C:4]([SH:18])[N:3]=1.Cl[CH2:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24]([NH2:26])=[O:25].C(=O)(O)[O-].[Na+].NC1C(C#N)=C(C2CCCCO2)C(C#N)=C(SCC2N=C(C3C=CC(Cl)=CC=3)SC=2)N=1>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:18][CH2:20][C:21]2[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=2)[C:24]([NH2:26])=[O:25])[C:5]([C:16]#[N:17])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:7]=1[C:8]#[N:9]

Participants

6

Reactant 4

HCID 516892Sodium BicarbonateHCID 7371453-Chloromethyl-benzamideHCID 24959059HCID 24959059, compoundHCID 178510477HCID 178510477, compound

Product 1

HCID 24961262HCID 24961262, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

50 mg (0.14 mmol) of the compound from Example 31A, 36 mg (0.21 mmol) of 3-(chloromethyl)benzamide and 48 mg (0.58 mmol) of sodium bicarbonate in 2.0 ml of dry DMF are reacted analogously to the preparation of the compound of Example 14.

Sources & evidence

ORD record
ord-cb6cbfdecfad4ef4b593703e6f2fe26b
Source dataset
uspto-grants-2012_11
Patent number
US08304412B2

Reaction notes

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