反应详情

In the same manner as in Example 55 and using 2,5-dimethyl-1,3-oxazole-4-carboxylic acid (65.0 mg, 0.462 mmol), tetrahydrofuran (5 mL), thionyl chloride (77.0 μL, 0.888 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (129 mg, 0.399 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (148 mg, 83%) was obtained as a white solid.