反应详情

In the same manner as in Example 55 and using 5-methyl-1,3-thiazole-4-carboxylic acid (63.1 mg, 0.441 mmol), tetrahydrofuran (5 mL), thionyl chloride (77.0 μL, 0.888 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (129 mg, 0.399 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (140 mg, 78%) was obtained as a white solid.