反应详情

In the same manner as in Example 55 and using 1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid (69.1 mg, 0.448 mmol), tetrahydrofuran (5 mL), thionyl chloride (78.0 μL, 0.899 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (132 mg, 0.408 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (102 mg, 55%) was obtained as a white solid.