反应详情

HATU (0.104 g, 0.272 mmol) was added to a solution of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.056 g, 0.182 mmol), 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylic acid (0.050 g, 0.182 mmol) and DIPEA (0.048 mL, 0.272 mmol) in DMF (1.5 mL). The mixture was stirred at RT for 1.5 h. The reaction mixture was diluted with ethyl acetate and water. The organic layer was washed with water and brine, dried over sodium sulfate, and the solvent was evaporated. The residue was purified by column chromatography (hexane/EtOAc) to give the title compound (0.056 g, 48%) as an off-white solid. 1H NMR (400 MHz, CDCl3): δ ppm 9.74 (s, 1H), 7.78 (s, 1H), 7.44 (d, 1H), 7.27-7.37 (m, 2H), 7.21 (dd, 1H), 7.08-7.13 (m, 1H), 6.98 (d, 1H), 6.74-6.86 (m, 3H), 6.63 (s, 1H), 4.66 (d, 2H), 1.50 (s, 9H). MS: m/z 569 (M+1).

1. washThe organic layer was washed with water and brine
2. dry with materialdried over sodium sulfate
3. customthe solvent was evaporated
4. customThe residue was purified by column chromatography (hexane/EtOAc)