Acetic Acid → HCID 68478950, compound

HRID 1876247Notes

Reaction equation

HRID 1876247 reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].[C:12](O)(=O)[CH3:13].[CH2:16](O)[CH3:17]>C1COCC1>[CH:17]1([CH2:12][CH2:13][N:1]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4](=[O:5])[C:2]2=[O:3])[CH2:16][CH2:7][CH2:6][CH2:4][CH2:2]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 702EthanolHCID 7054Isatin

Product 1

HCID 68478950HCID 68478950, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-(2-Cyclohexyl-ethyl)-isatine (170 mg, 0.73 mmol) previously obtained (see isatine 3 in table 5) and Benzenesulfonyl hydrazide (126 mg, 0.73 mmol) in 19 ml of a solution of acetic acid, ethanol and THF (20%, 40%, 40%) is stirred at room temperature for 12 h. After concentration, a yellow precipitate is filtered and washed with ethanol to afford a desired product. M: 54 mg, Yield: 20%

Sources & evidence

ORD record
ord-d31679648807496698bcec33dea7bf51
Source dataset
uspto-grants-2012_11
Patent number
US08309595B2

Reaction notes

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