反应详情

The compound (50 mg, 0.13 mmol) prepared in Example 27 was dissolved in N,N-dimethylformamide (2 ml). Morpholine (17 mg, 0.20 mmol), EDC (43 mg, 0.23 mmol) and HOBT (36 mg, 0.26 mmol) were added thereto, and the mixture was stirred for 8 h at room temperature. After completion of the reaction, saturated sodium bicarbonate solution was added. The mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure, and concentrated. The residue was purified by column chromatography to give the title compound (22 mg, Yield 37%).

1. additionwas added
2. extractionThe mixture was extracted with ethyl acetate
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. distillationThe filtrate was distilled under reduced pressure
6. concentrationconcentrated
7. customThe residue was purified by column chromatography