Hydrochloric Acid → (4-Benzyloxy-phenyl)-(6-(3-methyl-[1,2]oxazol-4-yl)-quinazolin-4-yl)-amine

HRID 187638Notes

Reaction equation

HRID 187638 reaction equation
[Ag:60]=[O:61].[CH2:28]([Sn:29]([CH2:30][CH2:31][CH2:32][CH3:39])([c:33]1[c:34]([CH3:38])[n:35][o:36][cH:37]1)[CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH3:46].[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][c:24]([I:27])[cH:25][c:26]23)[cH:14][cH:15]1.[CH3:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH3:53].[ClH:1].[O:54]1[CH2:55][CH2:56][O:57][CH2:58][CH2:59]1>>[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][c:24](-[c:33]4[c:34]([CH3:38])[n:35][o:36][cH:37]4)[cH:25][c:26]23)[cH:14][cH:15]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 312751,4-DioxaneHCID 92152Silver(II) oxideHCID 108940213-Methyl-4-(tributylstannyl)isoxazoleHCID 21951950(4-Benzyloxy-phenyl)-(6-iodoquinazolin-4-yl)-amine

Product 1

HCID 22609816(4-Benzyloxy-phenyl)-(6-(3-methyl-[1,2]oxazol-4-yl)-quinazolin-4-yl)-amine

Sources & evidence

ORD record
ord-e975dcd53b2e4ee782104a11d318b283
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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