反应详情

温度

50 °C

An N,N-dimethylformamide (5 ml) suspension of 2-chloro-6-((S)-3-methylmorpholin-4-yl)-9H-purine (839 mg, 3.31 mmol), 1-iodo-2-methylpropane (730 mg, 3.97 mmol), and potassium carbonate (594 mg, 4.30 mmol) was stirred at 50° C. for 4 hours. The reaction mixture was returned to room temperature. Ethyl acetate was added to the reaction mixture and the resulting mixture was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and, after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography (hexane:ethyl acetate=7:3) to give the title compound (868 mg, 85%) as an amorphous substance.

1. customwas returned to room temperature
2. washthe resulting mixture was washed with water and saturated brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationafter filtration
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was purified by flash silica gel column chromatography (hexane:ethyl acetate=7:3)