Potassium Carbonate → N-benzyl-6-chloro-N-(1-methylethyl)pyrazin-2-amine

HRID 1877851Notes

Reaction equation

HRID 1877851 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH2:9]([NH:16][CH:17]([CH3:19])[CH3:18])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].CC(N(C)C)=O>O>[CH2:9]([N:16]([CH:17]([CH3:19])[CH3:18])[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 31374DimethylacetamideHCID 66024IsopropylbenzylamineHCID 785042,6-Dichloropyrazine

Product 1

HCID 61699183N-benzyl-6-chloro-N-(1-methylethyl)pyrazin-2-amine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 2,6-dichloropyrazine (7.45 g), N-benzylpropan-2-amine (12.5 mL), potassium carbonate (10.4 g) and DMA (50 mL) was stirred at 80° C. for 15 hr. Water (100 mL) was added, and the mixture was extracted with ethyl acetate.

Workup

  1. extractionthe mixture was extracted with ethyl acetate

Sources & evidence

ORD record
ord-92af8d12369046aa9789b250a4733aeb
Source dataset
uspto-grants-2012_11
Patent number
US08314088B2

Reaction notes

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