Hydrochloric Acid → HCID 57448048, compound

HRID 1878949Notes

Reaction equation

HRID 1878949 reaction equation
[CH3:1][O:2][C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:26][CH2:27][CH3:28].Cl>C(#N)C>[CH3:1][O:2][C:3]1[C:8]([C:9]([F:11])([F:10])[F:12])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:13]1[CH2:18][CH2:17][N:16]([CH2:26][CH2:27][CH3:28])[CH2:15][CH2:14]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 57448040HCID 57448040, compound

Product 1

HCID 57448048HCID 57448048, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 4-[2-methoxy-3-(trifluoro-methyl)phenyl]piperidine (0.38 g, 1.47 mmol), acetonitrile (40 ml), potassium carbonate (0.4 g, 3.7 mmol) and 1-iodopropane (0.115 ml, 1.47 mmol). Yield: 0.33 g (74%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 235.5° C. MS m/z (relative intensity, 70 eV) 301 (M+, 7), 273 (22), 272 (bp), 229 (6), 159 (13).

Workup

  1. customPreparation
  2. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-4d4c4a4d7a124737a1513f31ebda613e
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

Loading…